Postdoctoral Position in Cancer Prevention Research Using Chemical and Biochemical Approaches

Stephen S. Hecht's laboratory in the Carcinogenesis and Chemoprevention Program, Masonic Cancer Center, University of Minnesota, has a postdoctoral position available, starting this spring or summer, for approximately 2 years. The laboratory is housed in the modern Cancer and Cardiovascular Research Building and focuses on mechanisms and prevention of cancer induced by environmental agents and tobacco products. All projects use rigorous chemical and biochemical approaches to identify and quantify specific metabolites and DNA damage products. Analyses are frequently based on structure determination and analytical quantitation by mass spectrometric methods in a modern multi-instrument facility next to the laboratory. Some recent publications are listed here:

Cheng, G., Guo, J., Carmella, S.G., Lindgren, B., Ikuemonisan, J., Jensen, J., Hatsukami, D.K., Balbo, S., and Hecht, S.S. Increased acrolein-DNA adducts in buccal brushings of e-cigarette users. Carcinogenesis 43: 437-444 doi:10.1093/carcin/bgac026, 2022.

Chen, M., Carmella, S.G., Lindgren, B.R., Luo, X., Ikuemonisan, J., Niesen, B., Thomson, N.M., Murphy, S.E., Hatsukami, D.K., and Hecht, S.S. Increased levels of the acrolein metabolite 3-hydroxypropyl mercapturic acid in the urine of e-cigarette users. Chem. Res. Toxicol. doi: 10.1021 acs.chemrestox.2c00145, 2022.

Park, S.L., Le Marchand, L., Cheng, G., Balbo, S., Chen, M., Carmella, S.G., Thomson, N.M., Lee, Y., Patel, Y.M., Stram, D.O., Jensen, J., Hatsukami, D.K., Murphy, S.E., and Hecht, S.S. Quantitation of DNA adducts resulting from acrolein exposure and lipid peroxidation in oral cells of cigarette smokers from three racial/ethnic groups with differing risks for lung cancer. Chem. Res. Toxicol. doi: 10.1021 acs.chemrestox.2c00171, 2022.

Li, Y. and Hecht, S.S. Mass spectrometric quantitation of N'-nitrosonornicotine-1-N-oxide in the urine of cigarette smokers and smokeless tobacco users. Chem. Res. Toxicol. 35: 1579-1588 doi: 10.1021/acs.chemrestox.2c00195, 2022.

Responsibilities:

This position involves approximately 80% laboratory research (wet chemistry sample analysis, mass spectrometry, etc.) and 20% compiling and reporting of results for publication.

All required qualifications must be documented on application materials.

Minimum qualifications: Ph.D. in analytical chemistry, biochemistry, organic chemistry, or closely related area.

The Masonic Cancer Center (MCC) is an NCI-designated Comprehensive Cancer Center dedicated to cancer research, education, and patient care for the citizens of Minnesota and the surrounding region. Since the time of the first award in 1997, there has been consistent growth of the membership and research base, enabling our center to further advance our knowledge and enhance care for our catchment area. We are driven to be the choice academic healthcare environment for patients, clinicians, scientists and students who seek exceptional, compassionate, precision cancer therapy; innovative clinical trials and prevention programs; cutting-edge research opportunities; and outstanding advanced education.

Working at the University

At the University of Minnesota, you'll find a flexible work environment and supportive colleagues who are interested in lifelong learning. We prioritize work-life balance, allowing you to invest in the future of your career and in your life outside of work.

The University also offers a comprehensive benefits package that includes:

• Competitive wages, paid holidays, and generous time off
• Continuous learning opportunities through professional training and degree-seeking programs supported by the
• Low-cost medical, dental, and pharmacy plans
• Healthcare and dependent care flexible spending accounts
• University HSA contributions
• Disability and employer-paid life insurance
• Employee wellbeing program
• Excellent retirement plans with employer contribution
• Public Service Loan Forgiveness (PSLF)
• Financial counseling services
• Employee Assistance Program with eight sessions of counseling at no cost

Please visit the for more information regarding benefits.

Applications must be submitted online. To be considered for this position, please click the Apply button and follow the instructions. You will be given the opportunity to complete an online application for the position and attach a cover letter and resume.

Additional documents may be attached after application by accessing your "My Job Applications" page and uploading documents in the "My Cover Letters and Attachments" section.

To request an accommodation during the application process, please e-mail employ@umn.edu or call (612) 624-UOHR (8647).

The University recognizes and values the importance of diversity and inclusion in enriching the employment experience of its employees and in supporting the academic mission. The University is committed to attracting and retaining employees with varying identities and backgrounds.

The University of Minnesota provides equal access to and opportunity in its programs, facilities, and employment without regard to race, color, creed, religion, national origin, gender, age, marital status, disability, public assistance status, veteran status, sexual orientation, gender identity, or gender expression. To learn more about diversity at the U:

Any offer of employment is contingent upon the successful completion of a background check. Our presumption is that prospective employees are eligible to work here. Criminal convictions do not automatically disqualify finalists from employment.

The University of Minnesota, Twin Cities (UMTC)

The University of Minnesota, Twin Cities (UMTC), is among the largest public research universities in the country, offering undergraduate, graduate, and professional students a multitude of opportunities for study and research. Located at the heart of one of the nation's most vibrant, diverse metropolitan communities, students on the campuses in Minneapolis and St. Paul benefit from extensive partnerships with world-renowned health centers, international corporations, government agencies, and arts, nonprofit, and public service organizations.